Effect of gluten-free diet on interferon gamma (IFN-γ) levels in patients with celiac disease
Abstract
Introduction: Celiac disease (CD) is a chronic autoimmune enteropathy, with inflammation mainly at the small intestine triggered by exposure to dietary gluten in genetically susceptible individuals. Inflammatory cytokines are implicated in the pathogenesis of CD, among them a relevant cytokine is interferon gamma (IFN-γ). Levels of this cytokine are altered in CD and its expression has been linked to intestinal mucosal damage. The gluten-free diet (GFD) is the only effective treatment for CD.
Aim: To determine the effect of GFD on circulating levels of IFN-γ in adult Paraguayan patients with CD.
Methods: 40 patients with CD were included, of which 20 did not present GFD due to recent diagnosis and 20 presented a GFD. In addition, 15 apparently healthy controls were included.
Results: Patients with CD without GFD had increased serum IFN-γ levels compared to the control group. In contrast, patients with GFD did not show differences in cytokine levels when compared to the control group.
Conclusion: Serum levels of the pro-inflammatory cytokine IFN-γ were found to be elevated in adult CD patients without a GFD compared to controls, which provides information about the inflammatory process present in this group of patients.
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References
(1) Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, et al. Celiac disease: A comprehensive current review. BMC Med. 2019;17(1):1–20.
(2) Al-toma A, Volta U, Auricchio R, Castillejo G, Sanders DS, Cellier C, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United Eur Gastroenterol J. 2019;7(5):583–613.
(3) Voisine J, Abadie V. Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease. Front Immunol. 2021;12:1–13.
(4) Björck S, Lindehammer SR, Fex M, Agardh D. Serum cytokine pattern in young children with screening detected coeliac disease. Clin Exp Immunol. 2015;179(2):230–5.
(5) Fabris M, Visentini D, De Re V, Picierno A, Maieron R, Cannizzaro R, et al. Elevated B cell-activating factor of the tumour necrosis factor family in coeliac disease. Scand J Gastroenterol. 2007;42(12):1434–9.
(6) Romero-Adrián TB, Leal-Montiel J, Fernández G. Celiac disease: Participation of Cytokines and Other Factors in the Immune Response. J Gastrointest Disord Liver Funct. 2015;1(1):15–23.
(7) Dunne MR, Byrne G, Chirdo FG, Feighery C. Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder. Front Immunol. 2020;11:1–14.
(8) Caruso R, Marafini I, Sedda S, Del Vecchio Blanco G, Giuffrida P, Macdonald TT, et al. Analysis of the cytokine profile in the duodenal mucosa of refractory coeliac disease patients. Clin Sci. 2014;126(6):451–8.
(9) Bragde H, Jansson U, Fredrikson M, Grodzinsky E, Söderman J. Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies. Cell Mol Life Sci. 2018;75(23):4385–401.
(10) Cataldo F, Lio D, Marino V, Scola L, Crivello A, Corazza GR, et al. Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency. Pediatr Allergy Immunol. 2003;14(4):320–4.
(11) Vorobjova T, Tagoma A, Oras A, Alnek K, Kisand K, Talja I, et al. Celiac disease in children, particularly with accompanying type 1 diabetes, is characterized by substantial changes in the blood cytokine balance, which may reflect inflammatory processes in the small intestinal mucosa. J Immunol Res. 2019;2019:11-17.
(12) Camarca A, Radano G, Di Mase R, Terrone G, Maurano F, Auricchio S, et al. Short wheat challenge is a reproducible in-vivo assay to detect immune response to gluten. Clin Exp Immunol. 2012;169(2):129–36.
(13) Goel G, Daveson AJM, Hooi CE, Tye-Din JA, Wang S, Szymczak E, et al. Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease. Clin Exp Immunol. 2020;199(1):68–78.
(14) Tye-Din JA, Skodje GI, Sarna VK, Dzuris JL, Russell AK, Goel G, et al. Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity. United Eur Gastroenterol J. 2020;8(1):108–18.
(15) Heydari F, Rostami-Nejad M, Moheb-Alian A, Mollahoseini MH, Rostami K, Pourhoseingholi MA, et al. Serum cytokines profile in treated celiac disease compared with non-celiac gluten sensitivity and control: A marker for differentiation. J Gastrointest Liver Dis. 2018;27(3):241–7.
(16) Manavalan JS, Hernandez L, Shah JG, Konikkara J, Naiyer AJ, Lee AR, et al. Serum cytokine elevations in celiac disease: Association with disease presentation. Hum Immunol. 2010;71(1):50–7.
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